2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W040329S
    2'-Deoxyadenosine-13C10,15N5 1987883-24-8 98%
    2'-Deoxyadenosine-13C10,15N5 is 13C and 15N-labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
    2'-Deoxyadenosine-13C10,15N5
  • HY-W040948R
    2-Ethylpyrazine (Standard) 13925-00-3 98%
    2-Ethylpyrazine (Standard) is the analytical standard of 2-Ethylpyrazine. This product is intended for research and analytical applications. 2-Ethylpyrazine is an endogenous metabolite.
    2-Ethylpyrazine (Standard)
  • HY-W040948S
    2-Ethylpyrazine-d5 1276197-45-5 98%
    2-Ethylpyrazine-d5 is the deuterium labeled 2-Ethylpyrazine. 2-Ethylpyrazine is an endogenous metabolite.
    2-Ethylpyrazine-d5
  • HY-W040971R
    Creosol (Standard) 93-51-6 98%
    Creosol (Standard) (2-Methoxy-4-methylphenol (Standard)) is the analytical standard of Creosol (HY-W040971). This product is intended for research and analytical applications. Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable.
    Creosol (Standard)
  • HY-W040971S
    Creosol-d4 20189-08-6 98%
    Creosol-d4 (2-Methoxy-4-methylphenol-d4) is the deuterium labeled Creosol (HY-W040971). Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable.
    Creosol-d4
  • HY-W041470R
    4-Methyl-1-phenyl-2-pentanone (Standard) 5349-62-2
    Chlorpromazine (hydrochloride) (Standard) is the analytical standard of Chlorpromazine (hydrochloride). This product is intended for research and analytical applications. Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis.
    4-Methyl-1-phenyl-2-pentanone (Standard)
  • HY-W042284R
    Tetradecyl acetate (Standard) 638-59-5 98%
    Tetradecyl acetate (Standard) is the analytical standard of Tetradecyl acetate. This product is intended for research and analytical applications. Tetradecyl acetate is a sex pheromone produced by Ctenopseustis obliquana females. Tetradecyl acetate can be used to disrupt the mating of pest species[1][2].
    Tetradecyl acetate (Standard)
  • HY-W042416R
    N,N-Dimethylacetamide (Standard) 127-19-5 98%
    N,N-Dimethylacetamide (Standard) is the analytical standard of N,N-Dimethylacetamide. This product is intended for research and analytical applications. N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease.
    N,N-Dimethylacetamide (Standard)
  • HY-W049735R
    N,N,O-Tridesmethylvenlafaxine (Standard) 149289-29-2
    Vardenafil (dihydrochloride) (Standard) is the analytical standard of Vardenafil (dihydrochloride). This product is intended for research and analytical applications. Vardenafil dihydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil dihydrochloride shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM respectively, while IC50s are >1000 nM for PDE3 and PDE4. Vardenafil dihydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil dihydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes-.
    N,N,O-Tridesmethylvenlafaxine (Standard)
  • HY-W050031R
    (S)-3-Hydroxybutanoic acid (Standard) 6168-83-8
    (S)-3-Hydroxybutanoic acid (Standard) is the analytical standard of (S)-3-Hydroxybutanoic acid (HY-W050031). This product is intended for research and analytical applications. (S)-3-Hydroxybutanoic acid is a metabolite and a disease marker for depression. (S)-3-Hydroxybutanoic acid is synthesized in the liver from acetyl-CoA and can be used by the brain as an energy source when blood sugar is low.
    (S)-3-Hydroxybutanoic acid (Standard)
  • HY-W050031S
    (S)-3-Hydroxybutanoic acid-d
    (S)-3-Hydroxybutanoic acid-d ((S)-β-Hydroxybutanoic acid-d) is the deuterium labeled (S)-3-Hydroxybutanoic acid (HY-W050031). (S)-3-Hydroxybutanoic acid is a metabolite and a disease marker of depression. 3-Hydroxybutyric acid is synthesized in the liver from acetyl-CoA, and can be used as an energy source by the brain when blood glucose is low.
    (S)-3-Hydroxybutanoic acid-d
  • HY-W050145R
    Levoglucosan (Standard) 498-07-7 99.97%
    Levoglucosan (Standard) is the analytical standard of Levoglucosan. This product is intended for research and analytical applications. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature.
    Levoglucosan (Standard)
  • HY-W051723R
    (R)-3-Hydroxybutanoic acid (Standard) 625-72-9
    (R)-3-Hydroxybutanoic acid (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid. This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones[1][2].
    (R)-3-Hydroxybutanoic acid (Standard)
  • HY-W068212S
    16-Hydroxyhexadecanoic acid-13C2
    16-Hydroxyhexadecanoic acid-13C2 (Juniperic acid-13C2) is the 13C-labeled 16-Hydroxyhexadecanoic acid (HY-W068212). 16-Hydroxyhexadecanoic acid (Juniperic acid) is one of the main monomers of cutin in Vicia faba flower petals. 16-Hydroxyhexadecanoic acid can be used as an internal standard for the measurement of hydroxy and hydroperoxy fatty acids in plasma
    16-Hydroxyhexadecanoic acid-13C2
  • HY-W089835R
    Sodium taurodeoxycholate hydrate (Standard) 207737-97-1
    Sodium taurodeoxycholate hydrate (Standard) is the analytical standard of Sodium taurodeoxycholate hydrate. This product is intended for research and analytical applications. Sodium taurodeoxycholate hydrate, a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Sodium taurodeoxycholate hydrate activates the S1PR2 pathway in addition to the TGR5 pathway.
    Sodium taurodeoxycholate hydrate (Standard)
  • HY-W094475D
    Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC 10034-99-8 98%
    Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC (Epsom salts, meets analytical specification of Ph. Eur. BP USP FCC) is currently the anticonvulsant of choice for the prevention and control of eclamptic fits and is also widely used as a tocolytic agent.
    Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC
  • HY-W101495S
    Boc-Leu-OH·H2O-13C 201740-80-9 98%
    Boc-Leu-OH·H2O-13C is a 13C-labeled Boc-Leu-OH (HY-W101495). Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity.
    Boc-Leu-OH·H2O-13C
  • HY-W105272R
    2′-Deoxyadenosine 5′-monophosphate disodium (Standard) 2922-74-9
    Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
    2′-Deoxyadenosine 5′-monophosphate disodium (Standard)
  • HY-W1120833
    m-PEG26-NHS ester
    m-PEG26-NHS ester is a PEG derivative. m-PEG26-NHS ester can be used for the study of Niemann-Pick type C1 disease.
    m-PEG26-NHS ester
  • HY-W1130518
    α-Phocaecholic acid 6879-45-4
    α-Phocaecholic acid is a nucleoside metabolite.
    α-Phocaecholic acid
Cat. No. Product Name / Synonyms Application Reactivity